Recently I have been tweaking some of my adsense ads, especially the ones on MyProfileResource.  If you have worked with adsense for a while you will know that tweaking is the key to sucess.  On MyProfileResource I really do not have the much room to work with because of the template im using.  I have a 160X600 skyscraper and 120X90 adlink on the right side.  I had the adlink at the top where the 160X600 is.  It was not doing so great so I decided to put the 160X600 at the top.   This little tweak really helped out, the 160X600 was getting a CTR of around .20% now it is getting around .90 – 1.0%.  So if you are having adsense troubles try changing some things around you will be suprised at the result!